We believe that maximum scientific success can only be achieved through cooperation. This requires a broad informed base, available (financial) resources and the right tools for collaborative work. The Leibniz Research Alliance “Bioactive Compounds and Biotechnology” has developed and aligned their measures to this metric: the advancement of science, raising of public awareness and provisioning of initial (seed money) funding.
Covid-19 seed money projects
Due to the current outbreak of the Sars-CoV-2 corona virus, the Leibniz Research Alliance Bioactive Compounds and Biotechnology funded smaller short-term scientific initiating projects in order to support the cooperation between the institutes (“seed money”).
- Dr. Aldrin Vasco Vidal (IPB) – Prof. Thomas Dobner (HPI): Synthesis of stapled peptide inhibitors of the ACE2 – CoV-2-RBD interaction (“Pin-Cov”)
- Prof. Gülsah Gabriel (HPI) – (HKI): Identification of novel compounds to inhibit SARS-CoV-2 replication in cell culture
- Dr. Victoria Shpacovitch (ISAS) – Prof. Carsten Watzl (IfADO): Development of SPR-based immunoassays for measuring anti-CoV-2 antibodies and for detecting interactions between CoV-2 spike protein and virus entry receptor ACE2 at very low concentrations.
One challenge in cooperation is the unequal access to scientific information, analysis tools and other resources. In general, the trend is moving towards open access publications and free access to databases and tools (GoFAIR, Open Source). However, numerous resources are not available for the public and therefore offer competitive advantages for their users. Data, expertise and sample material of scientific working groups represent often isolated resources of knowledge. Sharing these information with determined coordination and rules is conceivable for many scientists. So far, however, there is no well-organized platform with a secure and resource-saving manner. Practically all existing projects are organized centrally and mostly they lack support for the specific requirements of chemists. The project Leibniz Bioactives Cloud was therefore initiated to create a distributed (decentralized) platform for the exchange and analysis of data that correspond to certain issues of drug discovery.
Dr. Bernd Rupp and Dr. André Lampe launched a PodCast “Wirkstoffradio”, dedicated to the topic of drug discovery. This podcast is uniquely dedicated to small active compounds within the german podcasts. It deliveres first hand information and explanations from experts to the interested public.
Each story covers different aspects of its topic and is conviniently divided into different chapters accessible on its own. This is also how other media providers can link to parts or all of this podcasts.
The “Wirkstoffradio” links the work of the Research Alliance to the public and makes science more understandable to the public. It will also help to transfer knowledge on commonly used pharamceuticals or scientific techniques to the citizens.
Stay tuned – further episodes will follow regularly!
Seed Money projects
The Leibniz Research Alliance “Bioactive Compounds and Biotechnology” supports institutional cooperation among two or more alliance members and grants “Seed Money” funding. Short applications of maximum one page can be submitted twice per year.
- P. Stark, K. Franke, IPB Halle / J Sikorska, DSMZ Braunschweig: Hypericum metabolome and rhizosphere microbiome: a cross-kindom factory for bioactive compounds
- B. Westermann, T. Vogt, IPB Halle / F. Kloß, HKI Jena: Biosynthesis of bioactive amides by an enzymatic cascade reaction
- E. Freier, ISAS Dortmund / J. Hengstler, IfADo Dortmund: Investigation of inflammation-inducing effect of lipid droplets in hepatocytes with CARS microscopy (HepatoCARS)
- M. Dippe, IPB Halle / J. Thiele, IPF Dresden
Carrier-bound biocatalysts on magnetic surfaces
- H. Kries, HKI Jena – E. Freier, ISAS Dortmund
Enzyme evolution by catalysis enhanced diffusion (EVO-DIFF)
- T. Gutsmann, FZB Borstel – U. Nübel, DSMZ Braunschweig – B. Hube, HKI Jena
Generation of bacterial strain-specific antimicrobial peptides
- M. Behrens Leibniz-LSB@TUM Freising / N. Arnold IPB Halle: Isolation & functional screening of metabloites from mushrooms, a neglected source of organisms synthesizing strongly bitter tasting compunds
- Q. Besford, J. Schubert IPF Dresden / Z. Orinska, P. Hagemann FZB Borstel: Galactosylated glycogen-coated gold nanorods for photothermal eradication of prostate cancer cells
- V. Valiante HKI Jena / J. Cui INM Saarbrücken: Thermo-responsive magnetic nanoparticle biocatalysts for mediating multi-enzymatic reactions
- B. Westermann, IPB Halle /F. Kloß, HKI Jena
Improves fungicide bioactives by modifying naturally occurring fatty acids from fungi
- M. Dippe, IPB Halle / J. Thiele, IPF Dresden
Tailored adapter peptides for enzyme immobilization
- P. Rizzo, IPK Gatersleben / K. Franke, IPB Halle
Genotyping studies associated with bioactive compounds biosynthesis in Hypericum species
- B. Hube, HKI Jena / T. Gutsmann, FZ Borstel
The role of non-toxic peptides in Ece1 protein
- H. Guo, C. Beemelmanns, HKI Jena / M. Neumann‐Schaal, DSMZ Braunschweig
Metabolomic and Functional Analysis of Actinobacteria Associated with Fungus‐Growing Termites
- B. Hube, HKI, Jena / T. Gutsmann, FZ-Borstel, Borstel
The effects of the fungal toxin candidalysin on bacteria
- P. Stallforth, HKI, Jena / M. Weissenborn, IPB, Halle
Survival of the deadliest (SOFD)
- J. Thiele, IPF, Dresden / M. Weissenborn, IPB, Halle
Abiological catalysis by heme-carrying DNAzymes in DNA-polymer microgels (polyDNAcat)
- E. Freier, ISAS, Dortmund / M. Weissenborn, IPB, Halle
Multiplexing GC-MS analysis for a generic high throughput enzyme screen (MULTI-GC)
- G. Kaluđerović, IPB, Halle / J. Hengstler, IfADo, Dortmund
Fluorescence nanoparticles as drug carriers for natural product emodin
- B. Michels, LIN, Magdeburg / L. Wessjohann, IPB, Halle
Cognitive enhancement by natural compounds
- G. Kaluđerović, IPB, Halle / E. Freier, ISAS, Dortmund
Traceable nanomaterials for drug delivery
- A. Hamann, S. Frischbutter, DRFZ, Berlin / A. Brakhage, HKI, Jena / L. Wessjohann, IPB, Halle
Implementation of comprehensive screenings for novel immunomodulators within libraries of natural compounds