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EU-Openscreen General Director Wolfgang Fecke Guest Speaker at the Member Assembly of the Alliance – 25. Annual Meeting of the Leibniz Association

Steigenberger Hotel am Kanzleramt, Ella-Trebe-Straße 5, 10557 Berlin, Salon 1

Dr. Wolfgang Fecke, General Director of EU-OPENSCREEN followed our  invitation and presented the project, integrating high-capacity screening platforms throughout Europe, which jointly use a rationally selected compound collection, comprising up to 140.000 commercial and proprietary compounds collected from European chemists.


SEED MONEY PROJECTS – NEW CALL 2020 OPEN

The Leibniz Research Alliance calls for proposals for funding of short term scientific projects between two or more institutes of the alliance. The maximum budget pro project is in this call € 10.000 €.

Contact: wirkstoffe@ipb-halle.de

Submission deadline: 2. March 2020

Please use the attached template for the proposal (not longer than 1 pages). All information and the template for download is available here: Seed-Money_Vorlage-Antrag_Template-Proposal.

The elected committee will decide about funding and you will be informed thereafter.


PRIZE “LEIBNIZ BIOTECHNOLOGY PROCESS 2019”

Researcher team at the Leibniz Institute of Plant Biochemistry (IPB Halle) awarded

To honor the important field of new biotechnological processes, the Leibniz Research Alliance Bioactive Compounds and Biotechnology awarded the Prize “Leibniz Biotechnology Process 2019”. The research team of Professor Ludger A. Wessjohann and Dr. Martin Dippe at the Leibniz Institute of Plant Biochemistry (IPB) was honored for their work on the sustainable large-scale production process of the bitter-masking flavanone homoeriodictyol (HED).

Homoeriodictyol (HED) represents the active principle of the desert plant Eriodictyon californicum – a medicinal plant already used by indigenous population of Mexico. HED shows a pronounced bitter masking effect, which is why there is great interest in using this natural product in the food and pharmaceutical industries. HED, however, cannot be obtained in sufficient quantities from plant material as Eriodictyon cannot be grown and the wild stocks of the plant are threatened.

The aim of the project was therefore to develop a sustainable process for the large-scale production of HED. Chemically, it is a flavanone biosynthetically derived from the plant ubiquitous precursor naringenin. Naringenin is available in large quantities, it is a cheap, but hardly economically used waste product from press residues of orange juice production. The conversion of naringenin to HED occurs in two enzymatic steps (patents WO2016/050656A1, 15188136.4, WO2016/050656A1). Advantages of the method are that (I) a waste product is biotechnologically upgraded into a high-priced drug, and (II) it does not require the external addition of the above-mentioned costly cofactors, which are taken from the cellular base metabolism.


Berlin Science Week, Leibniz debates – Leibniz Theme  Day “Health”

As a part of the Berlin Science Week and the event “Leibniz debattiert” (“Leibniz Debate”), this time on the subject of vaccination/immunization, a Leibniz Theme Day took place on 5. November 2019 from 17:00 in Berlin.

Our LRA Bioactive Compounds and Biotechnology was presented for visitors of the event. Our presentation was supported by the colleagues of the Leibniz Research Cluster, our Wirkstoffradio-project and the Leibniz-Institute for Food Systems Biology at the Technical University of Munich.

Program flyer (in German): Flyer_Leibniz_debattiert_Impfen.

photo: Leibniz Gemeinschaft/Oliver Lang

photo left, left to right: Dr Sina Gerbach, Dr. Erik Freier, Dr. Anna Rusznyak, Dr. Vito Valiante (photo: Dr. Erik Freier)

photo right, left to right: Dr. Gisela Olias, Dr. Anna Rusznyak

 


First PhytoAD Symposium at the IPB on neuroactive substances from plants

On 21st and 22nd of October, scientists met at the PhytoAD Symposium in the IPB to present their latest research on plant bioactives. They discussed natural drugs from St. John’s wort (Hypericum perforatum), inflammation inhibitors from other medicinal plants and treatment approaches for Alzheimer’s disease. In between, external guests among the about 30 participants joined guided tours to visit the facilities and technical equipment of the institute. Read more


Congratulations to the new seed money project teams!

Fall 2019:

  • Maik Behrens, Leibniz-LSB@TUM Freising / Norbert Arnold, IPB Halle: Isolation&functional screening of metabloites from mushrooms, a neglected source of organisms synthesizing strongly bitter tasting compunds
  • Quinn Besford, Jonas Schubert, IPF Dresden / Zane Orinska, Philipp Hagemann, FZB Borstel: Galactosylated glycogen-coated gold nanorods for photothermal eradication of prostate cancer cells
  • Vito Valiante, HKI Jena / Jiaxi Cui, INM Saarbrücken: Thermo-responsive magnetic nanoparticle biocatalysts for mediating multi-enzymatic reactions

Spring 2019:

  • Martin Dippe, IPB Halle / Julian Thiele, IPF Dresden
    Trägergebundene Biokatalyse an magnetischen Oberflächen
  • Hajo Kries, HKI – Erik Freier, ISAS
    Enzyme evolution by catalysis enhanced diffusion (EVO-DIFF)
  • Thomas Gutsmann, FZB – Ulrich Nübel, DSMZ – Bernhard Hube, HKI
    Generierung Bakterien-Stamm-spezifischer Antimikrobieller Peptide

THE ALLIANCE WELCOMES NEW IT-COLLEAGUE AT IPB IN HALLE:

Fabian Mauz will support Bioactives Cloud-Team

Mr. Fabian Mauz has joined the IPB beginning of June 2019. He studied economic informatics at the Martin Luther University in Halle with specialisation in mathematical optimisation and statistics. He has 10 years of work experience as a software developer with JAVA and MATLAB (Price [it],Halle). Email: fabian.mauz@ipb-halle.de

The Bioactives Cloud Newsletter: Newsletter Leibniz-Cloud